The Advanced Technology X-ray (AT) and Passenger Imaging programme has seen a new generation of security equipment installed at a dozen airports.
Now, the programme is being rolled out to other major airports across the country.
The airports that will receive the new equipment over the coming months are as follows: Albuquerque, Atlanta, Baltimore-Washington, Boston, Chicago O'Hare, Dallas/Fort-Worth, Denver, Detroit, Indianapolis, Las Vegas, Los Angeles, Miami, New York John F. Kennedy, New York LaGuardia, Newark, Puerto Rico, Phoenix, Ronald Reagan Washington National, Washington-Dulles, San Francisco, Tampa.
By next year, over 900 of the new X-ray machines and 120 passenger imaging units will be deployed.
The new X-ray machines - known as millemetre wave scanners - produce multi-view, high-definition images.
The machines are intended to improve explosive detection, which TSA Administrator Kip Hawley says "remain the greatest threat" to airport security.
Concealed weapons or packages are also more visible to the new scanners.
A TSA statement said: "The advantages of AT X-ray include a greatly enhanced image with the ability to target novel threat items resulting in fewer bag checks and faster throughput".
Hawley added: "This major step-up in technology coupled with our enhanced security training for our officers will elevate security across the board".